Abstract
Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 micromol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition.
MeSH terms
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Administration, Oral
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Animals
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Blood Glucose / drug effects
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Diabetes Mellitus, Experimental / drug therapy
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Diabetes Mellitus, Experimental / metabolism
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Disease Models, Animal
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Diterpenes / chemical synthesis*
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Diterpenes / pharmacology
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Diterpenes / therapeutic use
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Mice
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Protein Kinase Inhibitors*
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Protein Kinases*
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Protein Serine-Threonine Kinases
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Pyruvate Dehydrogenase Acetyl-Transferring Kinase
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
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Triterpenes / chemical synthesis*
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Triterpenes / pharmacology
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Triterpenes / therapeutic use
Substances
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Blood Glucose
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Diterpenes
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Protein Kinase Inhibitors
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Pyruvate Dehydrogenase Acetyl-Transferring Kinase
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Triterpenes
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Protein Kinases
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Protein Serine-Threonine Kinases